ADRB2 Gly16Arg polymorphism, asthma control and lung function decline
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چکیده
منابع مشابه
ADRB2 Gly16Arg polymorphism, asthma control and lung function decline.
Arg/Arg homozygotes for the Gly16Arg polymorphism in the β₂-adrenoreceptor gene (ADRB2) have a reduced response to short-acting β₂-agonists but no effect has been associated with long-acting β₂-agonists (LABAs). We selected 604 subjects with current asthma from the European Community Respiratory Health Study to evaluate whether asthma control and lung function decline were associated with Gly16...
متن کاملLung function decline in asthma.
P rogressive decline in lung function in asthma has been well recognised but not fully explained. For example, in a Danish population study (the Copenhagen City Heart Study), three measurements of forced expiratory volume in one second (FEV1) were made over 15 yrs in 17,506 subjects, including 1,095 with asthma [1]. Asthmatics showed a decline in FEV1 of 38 mL?yr compared with 22 mL?yr in norma...
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STUDY OBJECTIVE We evaluated the longitudinal changes in lung function and the factors associated with FEV(1) changes over time in a sample of asthmatic subjects. SETTING FEV(1) measures were recorded every 3 months over a 5-year follow-up period. To compare all subjects independently of body size, FEV(1) values were normalized for the subject's height at the third power. We evaluated the pos...
متن کاملADRB2 Arg16Gly Polymorphism, Lung Function, and Mortality: Results from the Atherosclerosis Risk in Communities Study
BACKGROUND Growing evidence suggests that the Arg16Arg genotype of the beta-2 adrenergic receptor gene may be associated with adverse effects of beta-agonist therapy. We sought to examine the association of beta-agonist use and the Arg16Gly polymorphism with lung function and mortality among participants in the Atherosclerosis Risk in Communities study. METHODOLOGY AND PRINCIPAL FINDINGS We g...
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Severe asthma exacerbations are periods of intense airway inflammation that have been hypothesised to contribute to structural changes in the airways. If so, accelerated lung function decline over time should be more prevalent in adult patients with asthma who have frequent exacerbations than those without, but to date this has not been demonstrated. A cohort study was performed in order to inv...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2011
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.00146310